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Gliotoxin Size:10mg solid PubMed PMID: 21368229

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Description

PubMed PMID: 21368229

EPZ-6438 was orally dosed to mice at 250-500 mg/kg twice per day for 21-28 days

Formula: C10H12N2

ClH/c10-7-9(6-8(11)12)4-2-1-3-5-9

Tigecycline is a glycylcycline antibiotic developed by Francis Tally and marketed by Wyeth under the brand name Tygacil

Gliotoxin Size:10mg solid PubMed PMID: 21368229Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducible NF B activity by preventing IB degradation, which consequently induces host cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus

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