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1218942-37-0
but side effects were problematic and it is unclear whether cilomalast will be marketed
Chemical Name: sodium 5-amino-1
In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0
InChi: InChI=1S/2C26H21F3O3
IPA-3 Size:2mg solid 1218942-37-0IPA 3 is a potent and selective PAK1 inhibitor. IPA 3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF B activation. IPA 3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA 3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF B. IPA 3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse