PI3Kdelta inhibitor 1 ro-2-(4-methoxyphenyl)-4-oxo-1 5-benzothiazepin-5(2H)-yl]ethyl]methyl-d3-carbamic Acid 1-Chloroethyl Ester Smiles: CC1(C)CC(=O)C=C(C)[C@]1(O)/C=C/C(/C)=C\C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Smiles: CC1(C)CC(=O)C=C(C)[C@]1(O)/C=C/C(/C)=C\C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

1 μM and for a shorter time also shows a drop in Lys9 methylation

BrH/c1-4-5-9-16-15(11-12-18(2)3)13-14-8-6-7-10-17(14)16

Smiles: CC(C)CN(C[C@@H](O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNCC1=CC=CC(F)=C1)C(C)(C)C)S(=O)(=O)C1C=CC=C(N)C=1

Smiles: OCCN(C(=O)CC1C=CC(=CC=1)C(=O)NO)C1C=CC=CC=1

PI3Kdelta inhibitor 1 ro-2-(4-methoxyphenyl)-4-oxo-1 5-benzothiazepin-5(2H)-yl]ethyl]methyl-d3-carbamic Acid 1-Chloroethyl Ester Smiles: CC1(C)CC(=O)C=C(C)[C@]1(O)/C=C/C(/C)=C\C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OPI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3K inhibitor with an IC50 of 1. 3 nM. Product information CAS Number: 2242109 74 4 Molecular Weight: 558. 69 Formula: C27H38N6O5S Chemical Name: N [2 methoxy 5 (1 methyl 4 {[(3R) 1 [2 (oxan 4 yl)ethyl]piperidin 3 yl]methoxy} 1H pyrazolo[3,4 b]pyridin 6 yl)pyridin 3 yl]methanesulfonamide Smiles: CN1N=CC2=C1N=C(C=C2OC[C@H]1CN(CCC1)CCC1CCOCC1)C1C=C(NS(C)(=O)=O)C(=NC=1)OC