I have mixed feelings on Vampire Nocturnus, which was another Standard staple back in the day
Regeneration won't save your Spiders from every form of removal -- namely, exile effects and bounce spells
True, hands will likely not be that full mid to late game, but still, with many opponents, this thing can come in really big
The card then lets you fetch any card from your deck at the cost of three life
The best of these effects cost no mana, because costing mana impairs the whole ramp thing, but some untap cards that cost mana are still worth highlighting
Additionally, Manifest has transformed into Manifest Dread, a keyword which lets you look at the top two cards of your library, manifesting one and sending the other to the graveyard