AMI-1 free acid Size:2mg solid TCMDC-135051 hydrochloride is a highly

TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity

InChi: InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12

Due to BI-3406 blocking the negative feedback relief induced by MAPK inhibition

Smiles: CC1(C)CCC(C)(C)C2=CC(=CC=C12)NC(=O)C1C=CC(=CC=1)C(O)=O

7-bis(carboxymethyl)-10-{2-[4-(3-{[4-({2-[(2S)-2-cyano-2-hydrogeniopyrrolidin-1-yl]-2-oxoethyl}carbamoyl)quinolin-6-yl]oxy}propyl)piperazin-1-yl]-2-oxoethyl}-1

AMI-1 free acid Size:2mg solid TCMDC-135051 hydrochloride is a highlyAMI 1 free acid is a potent, cell permeable and reversible inhibitor of protein arginine N methyltransferases (PRMTs), with IC50s of 8. 8 M and 3. 0 M for human PRMT1 and yeast Hmt1p, respectively. AMI 1 free acid exerts PRMTs inhibitory effects by blocking peptide substrate binding. Product information CAS Number: 134 47 4 Molecular Weight: 504. 49 Formula: C21H16N2O9S2 Chemical Name: 4 hydroxy 7 {[(5 hydroxy 7 sulfonaphthalen 2