VX-770 Size:2mg solid 7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is

7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC)

GSK1904529A (72 h) inhibits tumor cells proliferation with IC50s ranges from 35 nM to >30 μM

and Vmax/Km values of 1

PubMed PMID: 21249167

and for cell-based pharmacological screening

VX-770 Size:2mg solid 7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) isVX 770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 45% cases of cystic fibrosis, and is included in a combination drug, lumacaftor ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel