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PubMed PMID: 2482342
) significantly attenuates systolic dysfunction in the MI animals
NLG919 was used at 10 µM final concentration in various in vitro assays
Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM
InChi: InChI=1S/C25H36O5/c1-7-13(2)22(28)30-21-14(3)10-24-11-16(9-17(12-26)20(27)25(21
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 PubMed PMID: 2482342BO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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