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SR-01000568996
Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice
Entrectinib potently blocks proliferation of Ba/F3-TEL-TRKB (IC50 of 2
Cancer Ther
(2007) Mol Cancer Ther
SNIPER(ER)-87 Catalog No.:M7563-10 SR-01000568996SNIPER(ER) 87 is a potent and selective estrogen receptor (ER) Degrader (Specific and Nongenetic IAP dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER) 87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen binding moiety 4 hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER) 87 also reduces ER levels and inhibits
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