RNF5 inhibitor inh-02 ophosphoric acid disodium salt hydrate (α and β mixture) InChiKey: ZJXHVYSDMUKUCA-UHFFFAOYSA-N

InChiKey: ZJXHVYSDMUKUCA-UHFFFAOYSA-N

suppresses the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK

covalent and orally active inhibitor of KRAS G12C with IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells

InChi: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity

RNF5 inhibitor inh-02 ophosphoric acid disodium salt hydrate (α and β mixture) InChiKey: ZJXHVYSDMUKUCA-UHFFFAOYSA-NRNF5 inhibitor inh 02 is a potent inhibitor of E3 ubiquitin ligase RNF5 RMA1. RNF5 inhibitor inh 02 leads to significant F508del CFTR rescue (EC50=2. 2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh 02 can be used for cystic fibrosis research. Product information CAS Number: 324579 65 9 Molecular Weight: 384. 50 Formula: C23H20N4S Chemical Name: N (4 benzyl 3 methyl 4,5 dihydro 1,2,4 thiadiazol 5 ylidene) N'