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Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1
either Fbxw7+/+ or Fbxw7mut/+
but not to vascular smooth muscle and endothelial cells
It suppressed the basal autophagic flux
Formula: C29H35F3N2O3
AGI-6780 - Mutant IDH2 Inhibitor. CAS# 1432660-47-3 60218 Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1AGI 6780, CAS No. 1432660 47 3, is a potent and selective IDH2 inhibitor. AGI 6780 inhibits the tumor associated mutant IDH2 R140Q. Treatment with AGI 6780 induced differentiation of TF 1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2 R140Q could have potential applications as a differentiation therapy for cancer. Product information CAS Number: 1432660 47 3 Molecular Weight: 481. 51