PA-8 Catalog No.:M27505-C Smiles: CC(C)(C)[C@@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(=O)N1CC(C1)C#N

Smiles: CC(C)(C)[C@@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(=O)N1CC(C1)C#N

Chemical Name: bis(1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1

Chemical Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyrazin-2-yl)pyrimidin-2-yl]amino}benzamide

InChiKey: NAUYISNCVNUUDK-UHFFFAOYSA-N

38 nM and 0

PA-8 Catalog No.:M27505-C Smiles: CC(C)(C)[C@@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(=O)N1CC(C1)C#NPA 8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA 8 inhibits the phosphorylation of CREB induced by PACAP in PAC1 , but not VPAC1 or VPAC2 receptor. PA 8 also inhibits PACAP induced cAMP elevation with an IC50 of 2 nM. Product information CAS Number: 878437 15 1 Molecular Weight: 342. 35 Formula: C17H18N4O4 Chemical Name: 2 amino 5 [3 methoxy 4 (prop 2 en 1 yloxy)phenyl] 3H,4H,5H,6H,7H,8H pyrido[2,3 d]pyrimidine