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3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)-acetamide
Smiles: CCS(=O)(=O)N1CCN(CC1)C1C=CC(=CC=1)NC1=NC(NC2CC2)=C(C=N1)C(N)=O
UNII-LXU5241LCL
1021/acsmedchemlett
It is a unctionalized cereblon ligand for PROTAC research and development
Pexidartinib G4-Amine 3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)-acetamidePexidartinib (PLX 3397) is a potent, orally active, selective, and ATP competitive colony stimulating factor 1 receptor (CSF1R or M CSFR) and c Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX 3397) exhibits 10 to 100 fold selectivity for c Kit and CSF1R over other related kinases. Pexidartinib (PLX 3397) induces cell apoptosis and has anti tumor activity. Product information CAS Number: 1029044 16 3 Molecular Weight: 417. 81
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