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and exhibits >50-fold selectivity for c-Met compared with various tyrosine and serine-threonine kinases
35)36/h4-16
incorporates an E3 ligase ligand plus a PEG1 linker with terminal amine ready for conjugation to a target protein ligand
a broad-spectrum antimetabolite with antineoplastic activity
InChi: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H
AHU-377 - CAS# 149709-62-6 thscopolamine Bromide and exhibits >50-fold selectivity forSacubitril, also known as AHU377, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. Product information
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