RIPK1-IN-3 ro-2-(2-phenylethyl)-5 6 7-trihydroxy-5 6 7 8-tetrahydrochromone pretreatment of the sGC reporter

pretreatment of the sGC reporter cell line with 10 μM ODQ for 3 h results in a significantly reduced efficacy of Vericiguat

Smiles: CC1CCN(CC1)C(=O)[C@@H](CCN1C=CC=C1C#N)NS(=O)(=O)C1C=CC=C2NC=CC=12

Chemical Name: 1-ethynylnaphthalene

Chemical Name: 6-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-N-methyl-4-{[(1S)-1-(oxan-4-yl)ethyl]amino}cinnoline-3-carboxamide

Smiles: C[C@H](CC)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

RIPK1-IN-3 ro-2-(2-phenylethyl)-5 6 7-trihydroxy-5 6 7 8-tetrahydrochromone pretreatment of the sGC reporterRIPK1 IN 3 (Example 38), a RIPK1 inhibitor, extracted from patent WO2018148626A1, possesses anti inflammatory proprieties. Product information CAS Number: 2242677 36 5 Molecular Weight: 472. 42 Formula: C22H19F3N6O3 Chemical Name: 5 {2 amino [1,2,4]triazolo[1,5 a]pyridin 7 yl} 2 methoxy N {1 [2 (trifluoromethoxy)phenyl]ethyl}pyridine 3 carboxamide Smiles: COC1=NC=C(C=C1C(=O)NC(C)C1=CC=CC=C1OC(F)(F)F)C1=CC2=NC(N)=NN2C=C1 InChiKey: PRNFQCKAJOAASO