Eleclazine hydrochloride xacin meglumine with a subnanomolar Kd toward

with a subnanomolar Kd toward PI3Kα and mTOR (0

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

3(34Dihydroxycinnamoyl)quinic acid

24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner

and reticulocyte count

Eleclazine hydrochloride xacin meglumine with a subnanomolar Kd towardEleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0. 7 uM. target: Na+ current. IC50: 0. 7 uM. In vitro: Eleclazine hydrochloride inhibits ATX II enhanced late INa in ventricular myocytes, shorten the ATX II induced prolongation of APD, MAPD, QT interval, and decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Inhibition by GS 6615 of ATX II enhanced late INa is strongly correlated with