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Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity
JNJ-31020028 was found to be ineffective
Smiles: C[C@@H]1O[C@@H](O[C@H]2[C@H](OC(=O)/C=C/C3=CC(O)=C(O)C=C3)[C@@H](CO[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)O[C@@H](OCCC3C=C(O)C(O)=CC=3)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
6-fold resistant to crenolanib
induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells
SU4312 Size:Contact [email protected] for quotation Pexidartinib (PLX-3397) induces cell apoptosisSU4312 is the racemate of (Z) SU4312 and (E) SU4312. (Z) SU4312 inhibits PDGFR and FLK 1 with IC50s of 19. 4 and 0. 8 M, respectively. (E) SU4312 inhibits PDGFR, FLK 1, EGFR, HER 2, and IGF 1R with IC50s of 24. 2, 5. 2, 18. 5, 16. 9 and 10. 0 M, respectively. Product information CAS Number: 5812 07 7 Molecular Weight: 264. 32 Formula: C17H16N2O Chemical Name: (3E) 3 {[4 (dimethylamino)phenyl]methylidene} 2,3 dihydro 1H indol 2 one Smiles: CN(C)C1C=CC(