PS48 - PDK1 Activator. CAS# 1180676-32-7 430 RKI-1447 is a Type I

RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif

MLN-9708 blocks BMSCs-induced MM cell proliferation

PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer

is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases

2015 Jun 17

PS48 - PDK1 Activator. CAS# 1180676-32-7 430 RKI-1447 is a Type IPS48, CAS No. 1180676 32 7, is a novel PDK1 (phosphoinositide dependent protein kinase 1) activator (Kd = 10. 3 M), which binds to the HM PIF binding pocket rather than the ATP binding site. PS48 has been used to enhance iPSC reprogramming from human epidermal keratinocytes and endothelial cells. Product information CAS Number: 1180676 32 7 Molecular Weight: 286. 75 Formula: C17H15ClO2 Synonym: PS 48 Chemical Name: 5 (4 Chloro phenyl) 3 phenyl pent 2