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5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62
InChiKey: LUHCYAOYQIFNRN-UHFFFAOYSA-N
Inhibition of β-catenin-TCF1 interaction delays differentiation of mouse embryonic stem cells
male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat
InChi: InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7
CD 1530 Size:Contact [email protected] for quotation 5-dioxoimidazolidine-based P2X(7) receptor antagonists asTarget: RAR, RAR and RAR Ki: 150, 1500, and 2750 nM CD1530 is a potent and selective RAR receptor agonist with Ki values of 150, 1500 and 2750 nM for RAR, RAR and RAR receptors, respectively . In addition, CD1530 shows moderate RAR selectivity in the transcriptional assay with AC50 value of 1. 8 nM. RAR is present in the majority of tissues while the distribution of RAR and is more selective . RAR mediated retinoic acid (RA) induced growth arrest and