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Kinetics experiments revealed that PF-03716556 has a competitive and reversible mode of action
Chemical Name: 1-((4-methoxy-3-methylphenyl)sulfonyl)piperidine
Stanetty P
InChi: InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9
The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo
Simvastatin - CAS# 79902-63-9 Size:Solid 2 mg Kinetics experiments revealed that PF-03716556Simvastatin is a competitive inhibitor of HMG CoA reductase. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Simvastatin is marketed under the trade name Zocor and is often prescribed in combination with ezetimibe to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy.
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