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Bryan King
SSR128129E inhibits FGF2-induced EC proliferation with an IC50 of 31±1
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
Formula: C26H26F3N3O3
MPI-0479605 (0
GSK-2981278 - CAS# 1474110-21-8 Catalog No.:M6485-10 Bryan KingGSK 2981278, CAS No. 1474110 21 8, is a highly potent and selective inverse agonist of retinoic acid receptor related orphan receptor gamma (ROR gamma). GSK 2981278 is a strong ROR selective inverse agonist that inhibits activation of the il17 promoter. GSK 2981278 robustly inhibits ROR mediated cytokine production at both the mRNA and protein level. GSK 2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK 2981278
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