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Formula: C26H36N6O3
Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=CC2NC(=NC=2C=C1)C1C=CC(C)=CC=1
inhibition of the JAK-STAT signaling pathway
An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6
with an IC50 of 167 nM
D-Cycloserine Catalog No.:M10601-10 Formula: C26H36N6O3Alobresib, also known as GS 5829, is a potent and selective BET inhibitor. GS 5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. GS 5829 inhibited CLL cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1 2, and MYC. IB modulation indicates that GS 5829 also inhibited NF B signaling. GS 5829 induced apoptosis resulted from an imbalance between