TRAM 39 13081 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexan-2-one

5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexan-2-one

6-dihydroxy-4-methyl-2-oxabicyclo[2

CAS Number: 69655-05-6

InChiKey: QUEWKNBREKFLND-HYQUBYKOSA-N

KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter

TRAM 39 13081 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexan-2-oneTRAM 39, 2 (2 chlorophenyl) 2, 2 diphenyl acetonitrile, is a potent, synthetic, selective inhibitor of intermediate conductance Ca2+ activated K+channels. TRAM 39 selectively block K Ca3 but do not inhibit other Ca2+ activated K+channels.[1,3] Intermediate conductance Ca2 activated K channels are the product of the IKCa1 genes and are important in regulating the membrane potential of colonic epithelial cells, and lymphocytes. The IKCa1 gene is also