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Watanabe H
Abstract 1045
[Epub ahead of print] PubMed PMID: 26257057
while the lower (0
Chemical Name: 8-((2-(2
GNE-317 O1138452 Watanabe HGNE 317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE 317 targets the PI3K pathway and can cross the BloodBrain Barrier. GNE 317 was identified as having physicochemical properties predictive of low efflux by P gp and BCRP. Studies in transfected MDCK cells showed that GNE 317 was not a substrate of either transporter. GNE 317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the
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