GZD824 - CAS# 1257628-77-5 ne Protease inhibitor Hydrochloride Ricietto AP

Ricietto AP

108(1291):1252-6

CAS Number: 3056-17-5

It also inhibited proliferation and activated apoptosis in patient-derived MM cells and neoplastic cells from patients with other hematologic malignancies

360A iodide is a selective stabilizer of G-quadruplex

GZD824 - CAS# 1257628-77-5 ne Protease inhibitor Hydrochloride Ricietto APOlverembatinib, also known as GZD824, is a novel orally bioavailable inhibitor against a broad spectrum of Bcr Abl mutants including T315I. GZD824 tightly bound to Bcr Abl(WT) and Bcr Abl(T315I) with K(d) values of 0. 32 and 0. 71 nM, respectively, and strongly inhibited the kinase functions with nanomolar IC(50) values. GZD824 potently suppressed proliferation of Bcr Abl positive K562 and Ku812 human CML cells with IC(50) values of 0. 2 and 0. 13 nM,