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449(1):151-9
and FGFR4 with IC50=60 nM
InChiKey: SSXYXSMMVMVYEV-UHFFFAOYSA-N
Torin-1 did not affect the survival of normal colon stem cells in vivo
Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)
PF-4136309 - CAS# 1341224-83-6 273 449(1):151-9PF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2
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