CM-272 Catalog No.:M12375-10 6-²H₅)phenyl]propyl]amino}propanoyl]pyrrolidine-2-carboxylate

6-²H₅)phenyl]propyl]amino}propanoyl]pyrrolidine-2-carboxylate

5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H

InChi: InChI=1S/C29H29F3N8O

(2007) Mol Cancer Ther

The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2

CM-272 Catalog No.:M12375-10 6-²H₅)phenyl]propyl]amino}propanoyl]pyrrolidine-2-carboxylateCM 272 is a first in class, potent, selective, substrate competitive and reversible dual G9a DNA methyltransferases (DNMTs) inhibitor. CM 272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM 272 inhibits cell proliferation and promotes apoptosis, inducing IFN stimulated genes and immunogenic cell death. Anti tumour Activity. Product information CAS Number: 1846570 31 7 Molecular Weight: