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resulting in accumulation of polyubiquitin
Smiles: N#CC1C=C(N=CC=1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C1=CC=CC=C1Cl)C(=O)NC1CC(F)(F)C1)C1=CC(F)=CN=C1
Smiles: OC(CNC1C=CC=CC=1)CN1C2=CC=C(Br)C=C2C2=CC(Br)=CC=C12
GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM
KRAS-C9 provides structure-based validation of a new allosteric regulatory site on Ras that is targetable in a mutant-specific manner
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid resulting in accumulation of polyubiquitinOTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos
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