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It inhibits prenylation of the CxxX tail motif
At low concentrations
AM251 alters mitochondrial physiology via proteolytic degradation of ERRα and attenuates mechanical allodynia and thermal hyperalgesia after burn injury
transformation
the KP-MRT-YM (YM) cell line is resistant to Palbociclib (IC50>10 µM)
AST-1306 (TsOH) Size:Solid 2 mg It inhibits prenylation of theAllitinib, also known as AST1306 and ALS 1306, is a potent, selective, irreversible ErbB2 and EGFR inhibitor. AST 1306 inhibits the enzymatic activities of wild type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell free and cell based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and
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