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InChi: InChI=1S/C45H72O16/c1-21(47)56-26-19-55-38(34(31(26)51)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5
Kunikata T
2014 Mar 15
InChiKey: RYHCACJBKCOBTJ-UHFFFAOYSA-N
and antitumor activity in preclinical studies
MK-4827 Tosylate Size:Solid 2 mg InChi: InChI=1S/C45H72O16/c1-21(47)56-26-19-55-38(34(31(26)51)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5Niraparib, also know as MK 4827, is an inhibitor of poly (ADP ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base excision repair (BER) pathway. Product information CAS Number: 1038915 73 9 Molecular Weight: 492. 59 Formula:
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