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2'-Deoxycytidine
InChi: InChI=1S/C18H23N5O9P2
significantly extends survival in a mouse model of FLT3-ITD AML at doses as low as 1 mg/kg when dosed orally once a day
EFdA-TP tetrasodium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT)
with IC50 of 2
ORM-15341 erine metabolite O-desmethyl Mebeverine acid 2'-DeoxycytidineORM 15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR HEK293 cells stably expressing full length hAR and an androgen responsive luciferase reporter gene construct. IC50 value: 38 nMTarget: androgen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM 15341 was 8 nM. ORM 15341 functions as a full antagonist for all tested mutant ARs ,
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