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1062368-24-4
960374-59-8
EPZ-6438 was orally dosed to mice at 250-500 mg/kg twice per day for 21-28 days
18(20):2069-2078
Thiemermann C
GSK-LSD1 - LSD1 Inhibitor. CAS# 2102933-95-7 0073 1062368-24-4GSK LSD1, CAS No. 2102933 95 7, is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i. e. LSD2, MAO A, MAO B). GSK LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Product
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