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Formula: C17H11Cl3N2O3
04] in exponentially growing DNA-PK proficient but not deficient cells
but not (R)-2-HG
An examination of the psychometric properties of the community integration questionnaire (CIQ) in spinal cord injury
IP administration of I-BET151 at 30 mg/kg once per day was shown to provide survival benefit in two distinct mouse models of murine MLL–AF9 and human MLL–AF4 leukaemia
AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid Formula: C17H11Cl3N2O3AZD8055, CAS No. 1009298 09 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 0. 8 nM). It has >1, 000 fold selectivity against all PI3K isoforms (, , , ) and other members of the PI3K like kinase family (ATM and DNA PK). It has no significant activity against a panel of 260 kinases at concentrations up to 10 M. AZD8055 inhibits the phosphorylation of mTORC1 downstream targets (p70S6K and 4E BP1) as well as phosphorylation of
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