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MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins
both in a dose-dependent manner
3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H
Oral administration of PLX-4720 at 20 mg/kg/day induces significant tumor growth delays and regressions in B-RafV600E-dependent COLO205 tumor xenografts
179461-52-0，is an inhibitor of calpains 1 and 2
Spautin-1 - Autophagy Inhibitor. CAS# 1262888-28-7 Catalog No.:M60003-10S MM-102 also specifically inhibits cellSpautin 1, CAS No. 1262888 28 7, is a potent autophagy inhibitor with an IC50 ~0. 74 M, and was discovered by an imaging based screen. It can selectively promote the degradation of Vps34 complexes. Mechanistic studies showed that Spautin 1 inhibited two ubiquitin specific peptidases, USP10 and USP13, which target the Beclin1 subunit of Vps34 complexes. Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and