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Inhibition of MMPs and ADAM/ADAMTS
2009 Mar 31
PubMed Central PMCID: PMC2702280
WYE-125132
decreased time to progression is observed for some KRAS-mutant tumors following GDC-0879 administration
MK-0752 Catalog No.:M7921-2 Inhibition of MMPs and ADAM/ADAMTSMK0752 is a synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell fate determination, cell survival, and cell proliferation. Product information CAS Number: 471905 41 6 Molecular Weight: 442. 90 Formula: