N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 CAS Number: 182431-12-5

CAS Number: 182431-12-5

but not in normal human dermal fibroblasts at concentrations up to 10 uM

Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1

(2011) Cancer Lett

Smiles: FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C34)C=N2)C=C1

N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 CAS Number: 182431-12-5N106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart