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11(11):2499-507
Arctiin is a lignan found in many plants of the Asteraceae family
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
CAS Number: 491-54-3
Smiles: [O-][N+](=O)C1C=CC(=CC=1)OC(=O)N1CCC(CC1)C(O)(C1=CC2OCOC=2C=C1)C1=CC2OCOC=2C=C1
Crizotinib Hydrochloride - CAS# 1415560-69-8 Size:Solid 2 mg 11(11):2499-507Crizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8
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