D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-10 Selective CDK7 inhibition with BS-181

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer

InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H

Bassilana F

NS11394 has a significantly reduced side effect profile in rat (sedation

Sephin1may have potential to safely prevent two protein misfolding diseases

D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-10 Selective CDK7 inhibition with BS-181D Sphingosine, CAS No. 123 78 4, is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL 17 and ameliorated the pathological symptoms.