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FRI0049 Preclinical Characterization of GS-9876
3-Bromopyruvate (Bromopyruvic acid)
GDC-0349 inhibited downstream markers of mTOR
Ethionamide is a second-line antitubercular agent that inhibits mycolic acid synthesis
Smiles: OC(=O)[C@H]1O[C@@H](OC2=CNC3=CC=C(Br)C(Cl)=C23)[C@H](O)[C@@H](O)[C@@H]1O
SB-334867 inib phosphate FRI0049 Preclinical Characterization of GS-9876SB 334867 (SB 334867A) is an excellent,selective and bloodbrain barrier permeable orexin 1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7. 4), 100 fold over 5 HT2B, 5 HT2C with pKi values of 5. 4 and 5. 3, respectively. SB 334867 reduces ethanol consumption and inhibits the acquisition of morphine induced sensitization to locomotor activity in vivo. Product information CAS Number: 249889 64 3 Molecular Weight: 355. 78 Formula:
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