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2-dihydroquinoline-3-carboxamido)acetic acid
InChi: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H
Tasisulam also inhibits VEGF-
and ATR in vitro
93 mL/min/kg
TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 2-dihydroquinoline-3-carboxamido)acetic acidTAK 243 (MLN7243), CAS No. 1450833 55 2, is a potent, selective and cell permeable small molecule inhibitor of the ubiquitin activating enzyme (UAE) at nM range. The ubiquitin activating enzymes, found more active in cancer cells than in normal healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via proteasome. TAK 243 treatment caused depletion of cellular ubiquitin conjugates, resulting in
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