Z-VDVAD-FMK 21843 twice daily for 16 d)

twice daily for 16 d) increases CD8+ T cells infiltration and reverses immunosuppression in mice

Formula: C19H19ClN6O4S3

Smiles: CN1CCN(CC2C=CC(=CC=2)C2=CN(C3CCC(O)CC3)C3=NC(NCCCC)=NC=C23)CC1

Smiles: CC(C)(CC1CC2=CC=CC=C2C1)NC[C@@H](O)COC1=CC(CCC(O)=O)=CC=C1C#N

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N1CC2C=CC=CC=2C#CC2C=CC=CC1=2

Z-VDVAD-FMK 21843 twice daily for 16 d)Jurkat T lymphocytes treated with an irreversible caspase 2 inhibitor, benzyloxycarbonyl Val Asp(OMe) Val Ala Asp(OMe) fluoromethyl ketone (Z VDVAD FMK), or stably transfected with pro caspase 2 antisense (Casp 2 AS) are refractory to cytochrome c release stimulated by etoposide1. When etoposide induced activation of pro caspase 2 is subverted by Z VDVAD FMK or stable transfection of pro caspase 2 antisense, cytochrome c release and other