Rilmenidine hemifumarate iKan 083 Smiles: O[C@@H]1CCCN[C@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O

Smiles: O[C@@H]1CCCN[C@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O

with an IC50 < 100 nM

658084-23-2

Formula: C23H24N2O

while binding to the low affinity site blocks the channel

Rilmenidine hemifumarate iKan 083 Smiles: O[C@@H]1CCCN[C@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=ORilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2 adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+ H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic