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Epub 2015 May 9
Smiles: COC1=CC=C(C=C1OC)/C(=C/C1=CC=C(S1)N1CCC(O)CC1)/C#N
199657-29-9 (Givinostat HCl)
The role of MDV-3100in the treatment of castration-resistant prostate cancer
InChi: InChI=1S/C23H26N2O2S/c1-3-18-9-11-20(12-10-18)23-25-21(17(2)27-23)15-28-16-22(26)24-14-13-19-7-5-4-6-8-19/h4-12H
GDC-0941 dimethanesulfonate - CAS# 957054-33-0 Catalog No.:M10946-2 Epub 2015 May 9Pictilisib, also known as Pictrelisib, GDC 0941, RG7321 and GNE0941 , is an orally bioavailable, and is a potent small molecule thieno[3,2 d]pyrimidine inhibitor of the class I phosphatidylinositol 3 kinase (PI3K) isoforms p100alpha and p100delta with potential antineoplastic activity. GDC 0941 selectively binds to PI3K isoforms in an ATP competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol 3,4,5 trisphosphate
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