![JAK1-IN-4 uinol A Smiles: CC1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@](O)(CO)[C@@H](C1)CC[C@@H]23](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M19040_1635297587.gif?v=1635297589)
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Smiles: CC1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@](O)(CO)[C@@H](C1)CC[C@@H]23
InChi: InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10
CAS Number: 1629166-02-4
selective and ATP competitive inhibitor of JAK3
Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate
JAK1-IN-4 uinol A Smiles: CC1(C)CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@](O)(CO)[C@@H](C1)CC[C@@H]23JAK1 IN 4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12. 8 M and >30 M for JAK1, JAK2, and JAK3, respectively. JAK1 IN 4 inhibits STAT3 phosphorylation in NCI H 1975 cells (IC50, 227 nM). Product information CAS Number: 2091134 35 7 Molecular Weight: 521. 59 Formula: C26H32FN9O2 Chemical Name: (2R) 2 [(3R) 3,4 dimethylpiperazin 1 yl] N (3 {5 fluoro 2 [(3 methoxy 1 methyl 1H pyrazol 4 yl)amino]pyrimidin 4 yl} 1H indol 7
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