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in RKO cells at 75 and 150 μM
The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202
InChi: InChI=1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8
7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3
Formula: C23H22FNO4
CM10 10400 in RKO cells at 75CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti cancer activity. Product information CAS Number: 692269 09 3 Molecular Weight: 321. 42 Formula: C20H23N3O Chemical Name: 2 (prop 2 en 1 yl) 6 {[(1 propyl 1H 1,3 benzodiazol 2