SN-38 Size:Solid 2 mg COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1

COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1

its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels

Formula: C9H8ClN5S

Body weight measurement and analysis reveal that the mice treated with WZB117 lost about 1 to 2 grams of body weight compared with the mock-treated mice with most of the weight loss in the fat tissue

0000000000000409

SN-38 Size:Solid 2 mg COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1SN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be