THZ1 - Covalent CDK7 Inhibitor. CAS# 1604810-83-4 284 the compounds library sets are

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Epub 2017 Apr 24

5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM)

Smiles: C(NC1N=CC=CN=1)C1C=CC(CNC2N=CC=CN=2)=CC=1

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin

THZ1 - Covalent CDK7 Inhibitor. CAS# 1604810-83-4 284 the compounds library sets areTHZ1, CAS No. 1604810 83 4, is a novel potent, selective and cell permeable irreversible CDK7 inhibitor with an IC50 ~3. 2 nM. THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell line profiling indicates that a subset of cancer cell lines, including human T cell acute lymphoblastic leukaemia (T ALL), have