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Chemical Name: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Nature Biotechnology 27
A Potent and Selective Inhibitor of Cdc42 GTPase
STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo as well as in vitro
R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested
BLU-9931 - CAS# 1538604-68-0 255 Chemical Name: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylateBLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor
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