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Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy

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Currently, four main models potentially responsible for T-cell hypersensitivity reactions have been hypothesized: (1) the hapten/prohapten model, according to which a drug binds covalently to an endogenous protein, forming a complex, that it is processed by antigen-presenting cells and recognized by a T cell receptor (TCR), developing a drug-specific immune response