PD173074 3295668 STF-62247 is a potent Autophagy

STF-62247 is a potent Autophagy Inducer

61 583 PMID: 28692295

InChi: InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11

Arch Gynecol Obstet

CAS Number: 839706-07-9

PD173074 3295668 STF-62247 is a potent AutophagyPD173074 is a small molecule FGFR3 selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM UC 14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1) S transition in a dose depending manner. In the mouse xenograft models using