OG-L002 - LSD1 Inhibitor. CAS# 1357302-64-7 60281 RGFP966 was used at 10

RGFP966 was used at 10 µM final concentration in various in vitro assays

and Smad8 phosphorylation

giving growth delays in A431 xenografts exceeding 50 days following oral administration

EPZ-6438 was used at 1 µM final concentration in vitro and in cellular assays

often upregulated or mutated in a variety of cancer cells

OG-L002 - LSD1 Inhibitor. CAS# 1357302-64-7 60281 RGFP966 was used at 10OG L002, CAS No. 1357302 64 7, is a highly potent and specific inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO A and MAO B with IC50 ~1. 38 M and 0. 72M respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG L002 suppressed primary lytic